Half an hour by car from:
Assisi – Cortona – Perugina – Trasimeno Lake – Gubbio – Borgo San Sepolcro
An hour by car from:
Florence – Orvieto –Todi – Spoleto – Urbino – Rimini – San Marino

From Milan – Bologna – Cesena
Take highway E45 to Perugia-Roma, exit Città di Castello Sud,
towards Trestina – Lugnano
From Rome – Orte
Take highway E45 to Perugia-Cesena, exit Promano, towards Trestina – Lugnano
From Florence
Take highway A1, exit Arezzo, towards Città di Castello – Trestina – Lugnano
From Fano and the Adriatic
Take highway E78 Flaminia, towards Gubbio –  Umbertide – Lugnano
From Cortona
Towards Città di Castello